2001.07.20 17:52
Szerző: Anonymous
Andi,
mTitle:
An association between sudden infant death syndrome (SIDS) and Helicobacter pylori infection.
Author:
Kerr JR , Al-Khattaf A , Barson AJ , Burnie JP
Source
Arch Dis Child, 83(5): 429-34 2000 Service Fee: $10.75 ; Copyright Royalties: $6.30
Abstract:
BACKGROUND: Helicobacter pylori has recently been detected in the stomach and trachea of cases of sudden infant death syndrome (SIDS) and proposed as a cause of SIDS. AIMS: To establish the incidence of H pylori in the stomach, trachea, and lung of cases of SIDS and controls. METHODS: Stomach, trachea, and lung tissues from 32 cases of SIDS and eight control cases were examined retrospectively. Diagnosis of SIDS was based on established criteria. Controls were defined by death within 1 year of age and an identifiable cause of death. Tissues were examined histologically for the presence of bacteria. Extracted DNA from these tissues was tested for H pylori ureC and cagA sequences by nested polymerase chain reaction and amplicons detected by enzyme linked immunosorbent assay (ELISA). The cut off for each ELISA for each of the tissue types was taken as the mean optical density plus two times the standard deviation of a range of negative controls. RESULTS: Ages of SIDS cases ranged from 2 to 28 weeks. Ages of controls ranged from 3 to 44 weeks. For the ureC gene, 25 SIDS cases were positive in one or more tissues compared with one of the controls. For the cagA gene, 25 SIDS cases were positive in one or more tissues compared with one of the controls. CONCLUSIONS: There is a highly significant association between H pylori ureC and cagA genes in the stomach, trachea, and lung of cases of SIDS when compared with controls.
Title:
Proposed link between Helicobacter pylori and sudden infant death syndrome.
Author:
Pattison CP , Marshall BJ
Source
Med Hypotheses, 49(5): 365-9 1997 Service Fee: $10.75 ; Copyright Royalties: $35.30
Abstract:
Helicobacter pylori may be linked to sudden infant death syndrome (SIDS) through synthesis of inflammatory cytokines, particularly interleukin-1, which can produce fever, activation of the immune system, and increased deep sleep. A relatively minor respiratory or enteric infection, together with overwrapping and prone sleep position could then induce terminal hypoxemia. Alternatively, H. pylori produces large amounts of urease which, if aspirated in gastric juice, could reach the alveolae, react with plasma urea, and produce ammonia toxicity leading to respiratory arrest. Epidemiological similarities between H. pylori and SIDS are presented along with possible transmission mechanisms for H. pylori which support this hypothesis.
Ezeket találtam gyorsan a Medline-on, de gondolom ezt Te is már megtetted.
Az Archives elég magas impakt faktorú lap, nem közöl hülyeséget. Arra nincs bizonyíték, hogy a helicobacter a cumi lenyalásával jut a babába, de ez egy lehetséges út, ilyen még a szájra puszi is, ami az angolszász országokban igen elterjedt.
Remélem segítettem.
Szandra